Routine Probiotic Use in Very Preterm Infants: Retrospective Comparison of Two Cohorts

Routine Probiotic Use in Very Preterm Infants: Retrospective Comparison of Two Cohorts

American Journal of Perinatology, 07/20/2012 Clinical Article

Bonsante F et al. – Administration of Lcr Restituo was well tolerated and associated with lower mortality and morbidities in this cohort. The results provide evidence in support of the hypothesis that this probiotic may reduce IRB.

Methods

  • Treatment with Lactobacillus rhamnosus Lcr35 (Lcr Restituo) (2 × 108 colony–forming units/12 h) was started early after birth and intention to treat was up to 36 weeks' gestation.
  • The main outcome was definite NEC.
  • Secondary outcomes were mortality, late–onset sepsis (LOS), cholestasis, isolated rectal bleeding (IRB), and time to reach full enteral feeding (FEF).

Results

  • A total of 1130 patients were included.
  • No adverse effects were observed.
  • Infants in PC presented a reduced rate of NEC (odds ratio [OR] 0.20; 95% confidence interval [CI] 0.07 to 0.58), mortality (OR 0.46; 95% CI 0.21 to 1.00), and LOS (OR 0.60; 95% CI 0.40 to 0.89) and achieved FEF significantly earlier.

Article from MDLinx

Print

Available Now!

PPRG6-500 Cover
The Pituitary Patient Resource Guide Sixth Edition is now available! Be one of the first to have the most up-to-date information. The Pituitary Patient Resource Guide a one of a kind publication intended as an invaluable source of information not only for patients but also their families, physicians, and all health care providers. It contains information on symptoms, proper testing, how to get a diagnosis, and the treatment options that are available. It also includes Pituitary Network Association's patient resource listings for expert medical care.

Buy Now